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World of Darkness Second Edition can refer to:
- Chronicles of Darkness: Revised Storytelling System Rulebook, the revised edition of the World of Darkness: Storytelling System Rulebook; this book was originally solicited under the title "World of Darkness Second Edition" before the name of the game was changed to Chronicles of Darkness
- The Revised Storytelling System, the updated version of the Storytelling System that was introduced in The God-Machine Chronicle (and the corresponding God-Machine Rules Update) and was updated further in the Chronicles of Darkness revised rulebook, referenced above
- A World of Darkness Second Edition, a sourcebook for Vampire: The Masquerade
- The Chronicles of Darkness, originally known as the "New" World of Darkness, which was the second setting by the World of Darkness name (after the Classic World of Darkness)