Tryphosa believed that her place as an undead would enable her to affect the visions of the future she witnessed, an opinion that disagreed with that of her childe, and eventually opened a rift between the two.
She acted as an advisor for Camilla of Rome, counseling him to march against the Brujah of Carthage, and joined forces with the Ventrue Lysander and the Toreador Adanaya in order to eradicate every last trace of demonic influence of the city.
After the Convention of Thorns, she was one of the Methuselahs that took part in the Great Prank, an event that cut off Dementation discipline from those Malkavians that had allied themselves with the Camarilla.
Her fate was unknown, but her childe, a Malkavian antitribu known as Rodolfo, suspects that she and her allies had something to do with the destruction of the Ravnos Antediluvian during the events of the Week of Nightmares.
Actually, Tryphosa had fallen into Torpor in the Czech city of Domazlice, where she stirred in 2011 only to be destroyed by the entire order of the Akritai, albeit with heavy losses. The monks found an exemplar of the Book of Nod in her Haven, as well as a collection of her own prophecies labelled the The Apostate Auguries.