The Tlacique are a bloodline of the Followers of Set that reside in South America. They possesses Protean instead of the clan discipline of Serpentis, and also know a unique type of Setite Sorcery called Nahuallotl. They have an enmity with both the Camarilla and Sabbat, reaching back to the time of Christopher Columbus, when the European Kindred came over to South America and all but wiped out their mortal civilization.

In the modern nights, more and more Tlacique come into action again, forming an alliance with the Pisanob branch of the Giovanni Necromancers.