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Tezacatlipoca can refer to:
- Tezcatlipoca, a god of the Atzlánti pantheon in Scion
- Tezcatlipoca, an ally of Huitzilopochtli in Vampire: The Masquerade?
- Tezcatlipoca, a totem spirit in Werewolf: the Apocalypse
- Tezcatlipoca, part of the pantheon in the Dark Kingdom of Obsidian in Wraith: The Oblivion
- Tezcatlipoca, a Malkavian who appears in the Vampire Storytellers Screen Second Edition for Vampire: The Masquerade