Santa Monica is one of the four main regions in Vampire: The Masquerade - Bloodlines, the PC game developed by Troika and published by Activision. It is the home of E. and the other Thin Bloods, the blood bank, Surfside Diner, Foxy Boxes, the pawnshop, the Ocean House Hotel, the Asylum nightclub, Mercurio, Bertram Tung, Jeanette Voerman and her sister Therese Voerman, your optional ghoul, and the hospital can all be found here, also it houses sites such as your apartment. Your character starts gameplay here.

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