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The term Promethean or Prometheans can refer to:
- Promethean: The Created
- Prometheans, the mystically reanimated protagonists of that game
- Prometheans, a sect in Vampire: The Dark Ages and Dark Ages: Vampire
- Prometheans, a type of magical construct in Mage: The Ascension
- The Promethean Brotherhood, a compact of hunters in Hunter: The Vigil