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Plasm or ectoplasm can refer to:
- Plasm (sometimes called ectoplasm), the physical substance that makes up a wraith's or plasmic's corpus in Wraith: The Oblivion
- Plasm, the mystical energy that the Bound use to fuel Manifestations in Geist: The Sin-Eaters
- Ectoplasm, the physical substance of ghosts and the Underworld in the Chronicles of Darkness, and one of the five humours of the Prometheans in Promethean: The Created