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Persephone can refer to:
- Persephone, the first of the Risen in Wraith: The Oblivion?
- Persephone Tar-Anis, a former vampiric Pentex official in Werewolf: The Apocalypse?
- Persephone Moore, childe of Maxwell in Vampire: The Requiem?
- Persephone, a god aligned with the Dodekatheon in Scion?