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Orpheus can refer to:
- Orpheus, a roleplaying game set in the Classic World of Darkness
- Orpheus, who may have been the Progenitor of the Ulgan Lineage in Promethean: The Created
- Orpheus, a Salubri in Vampire: The Masquerade
- The Orphic Circle, a group of mediums and necromancers in Wraith: The Oblivion