Unlike many of her peers, she never held a throne, instead preferring to wander the African continent. Tales within the Clan tell that she fought Set and managed to incapacitate him after he had turned against her sire. In the Modern Nights, she is an active part of the Inconnu and monitors the activities of the Followers of Set.
Given her name, she probably originated in Egypt.
Descendants of Nefer-meri-Isis have acute awareness, as a result of their progenitor's self-sufficiency. They find it harder to obey orders. Many Ventrue antitribu with an affinity for Auspex descend from her line.