From the White Wolf Wiki, the most complete White Wolf reference

A Lupus is a Garou who was born as and raised as a wolf. Many Lupus are familiar with Gaia and bear a strong grudge towards humans for their tampering; this frequently extends to Homid Garou.

Advantages of Lupus include:

• High starting Gnosis.
• A deep familiarity with Gaia and the wilderness.
• Heightened senses (especially sight and smell).
• The strongest natural form.

Disadvantages of Lupus are:

• Limited starting abilities, especially things dealing with technology or human society.
• A simpler viewpoint and limited ability to look at things logically.

Lupus may recieve the starting Gift of Heightened Senses or Leap of the Kangaroo.