Last Daughter of Eve

From the White Wolf Wiki, the most complete White Wolf reference

In Cainite eschatology, the Last Daughter of Eve is a mortal woman, identified by a moon-shaped birthmark. She will be a critical figure in deciding the fate of all creatures during Gehenna. Various Gehenna Cults spend a lot of time looking for girls who meet the Last Daughter's (admittedly vague) description.

Her title is taken to imply that before Gehenna, human fertility will drop off, an event supported by Days of Fire.