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c. 8000 BC
In life a warrior renowned for his cruelty and inhuman treatment of his captives, the Eldest embraced him to allow him to act upon his whims. Kartarirya changed his gender and is by now a multi-armed Methuselah who considers all of India to be her personal stalking grounds.
Kartarirya tried impersonating Karttikeya, the god of war, only to discover the Brahmans wielded their faith as weapons and saw through such artifice. Surprisingly, in its search to find worshipers among the growing Vedic pantheon, Kartarirya came to understand and appreciate their religion. The multi-limbed divinities represented multiple states of beings, interpretations and personalities. While the divinities were certainly terrifying to behold, the Indians accepted the complex and often conflicting gods and precepts as natural. Enamored with the concept of multifaceted existence and perception, Kartarirya geared its transcendence toward that effort. Instead of seeking worship, Kartarirya sought to remold itself into a creature that could exist in multiple states of awareness simultaneously.
Kartarirya fought against encroaching Cainite presence following the conquests of Alexander the Great. She fought a Nosferatu Methuselah and now dwells in its domicile on the isle of Sri Lanka. By the time of the Final Nights, she rests in Torpor.
While Clanbook: Tzimisce Revised can be read to imply that Kartarirya is the first childe of Tzimisce, Players Guide to High Clans explicitly states that Ionache was the Eldest's first childe. The explicit statement in the latter would override the implication that could be read into the former.
That said, it is worth noting that the Tzimisce of Dark Medieval Europe could very well remain unaware of Kartarirya's existence, thus explaining her absence from the clan's history in that book, even if she is not in fact the Eldest's first childe.