Karen Anatos, born as Lily Thorn, is an vampire actress and occupies the fifth place on the Red List.
In life, Lily Thorn was a actress mostly starring in semi acclaimed Horror movies. During a scene in the German Black Forest, she fell into a river and was saved by the Gangrel Methuselah Brunhilde, who had watched the filming team for quite some time. After that, Brunhilde embraced her and placed her for the camera team to find.
After the incident, Lily Thorn decided to continue filming, despite feeling the change that had been wrought upon her. Drawing most of her knowledge about vampirism from Hollywood movies, she decided to make another vampire, feeding the director her vitae. In doing so, she transformed Karl Williams into a ghoul. Together, the two returned to Hollywood, where they made plans for Lily's future career. Lily agreed to periodically leave the business and reemerge as a new personality. When Lily retired, a fresh-faced star — her black-haired daughter, Rose — assumed the actress’ place in the mortal world. When Rose died in a car accident, a television personality with shocking red hair named Ophelia Vine shot up out of nowhere during the 1970s.
Her game was noticed by the Camarilla, who were content with letting her be. The change came when she ghouled a fan live on television. After a failed attempt to take her out, she was placed on the Red List, for public threatening of the Masquerade. Despite that, three Clans are indifferent - the Gangrel, the Brujah and the Toreador - and Los Angeles' current political situation makes it difficult to reach her.
- Karen Anatos bears a close semblance to the character Karen Anotos from Clanbook: Gangrel and Encyclopaedia Vampirica, who was Embraced by a fan during a filming and similarly has no idea that there is a wider vampire community. It can be assumed that the two are meant to be the same person (especially since the original Onyx Path outline for the Red List lists her as Karen Anotos).
- Her sire, Brunhilde, is of the sixth Generation, so Karen Anatos should have been seventh generation. This is likely an oversight from the writers or she has, unknowingly, committed Diablerie.