Ghemalish, named for Caine's palace Ghemal in the First City, is believed by the Tal'mahe'ra to be the language actually spoken in Enoch. It is regarded as etymological root of the Indo-Dravidian, Egyptian, Sumerian, and Mixe-Zoque languages.

The Tal'mahe'ra uses Ghemalish as a secret language, with numerous of their titles originating in that tongue. Enochian is a phonetic transliteration of Ghemalish that has leaked outside the Hand.