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Descent can refer to:
- Descent, the search for Hell among the Unchained in Demon: The Descent
- Descent, the tenure of an Arisen's stay in the living world in Mummy: The Curse
- "Descent", a short story by Sam Chupp, published in the Vampire: The Masquerade anthology The Beast Within and the Classic World of Darkness anthology Strange City
- Descension, the goal of the Nephandi in Mage: The Ascension