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In Vampire: The Masquerade the term Blood Curse may refer to:
- The Curse of Hunger which the Baali inflicted on the Assamites during the Second Baali War
- The Blood Curse of the Tremere which the Camarilla used to alter the Assamites' clan weakness after the Treaty of Tyre
- The Blood Curse, a disease that ravaged Kindred worldwide during the Trilogy of the Blood Curse
In Vampire: The Requiem the term Blood Curse may refer to: