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The term Blood Curse may refer to:
- The Blood Curse, a disease that ravaged Kindred worldwide during the Trilogy of the Blood Curse for Vampire: The Masquerade
- The blood curse which the Camarilla used to alter the Assamites' clan weakness after the Treaty of Tyre in Vampire: The Masquerade
- Blood curses, described in the sourcebook "Mythologies" for Vampire: The Requiem