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Chronicles of Darkness: 1916
- 1914-1918: The First World War begins.
- 1915-1917: The Ottoman Empire systematically eradicates most of its Armenian minority.
- 1916-1917: During the 12 Battles of the Isonzo in northern Italy, the weather begins to turn to the worst, resulting in more deaths from hypothermia on both sides than from enemy bullets. It results in the worst military defeat Italy ever suffered, with 275,000 prisoners made on that day.
- Numerous ANZACs (Australian and New Zealand Army Corps) die in the horribly mismanaged Dardanelles campaign.
- The Spanish Flu spreads over Europe thanks to the movement of troops during the war.
- Blood refrigeration for transfusion purposes is invented.